At the start of this year, I decided that I would pursue brutal honesty and face discomfort instead of compromise. If something/someone goes against my gut, I simply will say no and/or state why I'll no longer pursue whatever it is.
I've often found the most massive change comes after facing a difficult situation. It will feel like my heart is about to pound out of my chest and my brain is in a frying pan but then something wonderful happens: massive sense of relief, growth and weight off my mind.
I've quit jobs, people and found more peace and focus.
In dealing with people, I simply state why something isn't working for me, (sometimes) what I like about them (if we've spent a lot of time together), and wish them well.
Ignoring people is the coward's way. It's a narcissist's tool for punishment. It says, "You don't matter but I'm going to leave this unresolved for my convenience." I don't want people to think that I think they don't matter. They absolutely do. We just don't have enough in common and I can't be a better friend to some people so I'd rather we not waste our time.